Academia Sinica Life Science Library -- Research Findings

:::

Research Findings

Inst. of Biomedical Sciences - 張雅貞 Chang, Ya-Jen

Journal 53 Book 0

Shao JS, Lai AC, Huang WC, Wu KC, Chi PY, Chang YM, (Chang YJ*). Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s. Journal of Clinical Investigation. , 2025-07.
Wang YC, Wu PH, Ting WC, Wang YF, Yang MH, Su TH, Su JY, Sun HI, Huang WM, Tsai PL, Wernig G, Ho PC, Wang L, Wu CT, Chang YL, Chen TC, Meng TC, Chang YM, Lai SL, Li CW, Ko TM, Yang KC, (Chang YJ), Chern Y, Kuo MC, Huang YT, Tzeng YS, Tang JL, Chen SY*. Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells. Nature Communications. 16, 5600, 2025-06.
Thio CL, Shao JS, Luo CH, (Chang YJ*). Decoding Innate Lymphoid Cells and Innate-like Lymphocytes in Asthma: Pathways to Mechanisms and Therapies. Journal of Biomedical Science. 32, 48, 2025-05.
Lai AC, Gonzalez-Cuesta M, Ho CH, Chi PY, Wu KC, Rocha G, Munoz-García JC, Angulo J, García Fernandez JM, (Chang YJ*), Ortiz Mellet C*. α-GalCer sp2-iminoglycolipid analogs as CD1d-dependent iNKT modulators: Evaluation of their immunotherapeutic potential in murine models of asthma and autoimmune hepatitis. European Journal of Medicinal Chemistry. 282, 117060, 2025-01. [JCR]　[WOS]
Lin YC, (Chang YJ), Gau SS, Lo CM, Yang RB*. SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation. Cardiovascular Research. cvae, 132, 2024-06. [JCR]　[WOS]
Luo CH, Lai AC, Tsai CC, Chen WY, Chang YS, Chung EJ, (Chang YJ*). Staphylococcus aureus exacerbates dermal IL-33-ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin. JCI Insight. 9(6), e166821, 2024-02. [JCR]　[WOS]
Thio CL, (Chang YJ*). Modulation of pulmonary group 2 innate lymphoid cell function in asthma: From inflammatory mediators to environmental and metabolic factors. Experimental and Molecular Medicine. 10.1038, 1-13, 2023-09. [JCR]　[WOS]
Tsai CH, Lai AC, Lin YC, Chi PY, Chen YC, Yang YH, Chen CH, Shen SY, Hwang TL, Su MW, Hsu IL, Maitland-van der Zee AH, McGeachie MJ, Tantisira KG, (Chang YJ*), Lee YL*. Neutrophil extracellular trap production and CCL4L2 expression influence corticosteroid response in asthma. Science Translational Medicine. 15, eadf3843, 2023-06. [JCR]　[WOS]
Luo CH, Lai AC*, (Chang YJ*). Butyrate inhibits Staphylococcus aureus aggravated dermal IL-33 expression and skin inflammation through histone deacetylase inhibition. Frontiers in Immunology. 14, 1114699, 2023-05. [JCR]　[WOS]
González-Cuesta M, Lai AC, Chi PY, Hsu IL, Liu NT, Wu KC, García Fernández M, (Chang YJ*), Ortiz Mellet C*. Serine-/Cysteine-Based sp2‑Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma. Journal of Medicinal Chemistry. 66, 4768-4783, 2023-03. [JCR]　[WOS]
Thio CL, Lai AC, Wang JC, Chi PY, Chang YL, Ting YT, Chen SY, (Chang YJ*). Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter–induced airway inflammation. JCI Insight. 7(23), e164157, 2022-12. [JCR]　[WOS]
Thio CL, Lai AC, Ting YT, Chi PY, (Chang YJ*). The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function. Cell Reports. 40, 111437, 2022-09. [JCR]　[WOS]
Chung EJ, Luo CH, Thio CL, (Chang YJ*). Immunomodulatory Role of Staphylococcus aureus in Atopic Dermatitis. Pathogens. 11, 422-432, 2022-03. [JCR]　[WOS]
Li LC, Chen WY, Chen JB, Lee WC, Chang CC, Tzeng HT, Huang CC, (Chang YJ), Yang JL. The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia. Biomedicines. 9, 1252, 2021-09. [JCR]　[WOS]
He YH, Yeh MH, Chen HF, Wang TS, Wong RH, Wei YL, Huynh TK, Hu DW, Cheng FJ, Chen JY, Hu SW, Huang CC, Chen Y, Yu J, Cheng WC, Shen PC, Liu LC, Huang CH, (Chang YJ), Huang WC. ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions. Molecular Therapy-Nucleic Acids. 25, 536-553, 2021-08. [JCR]　[WOS]
Chen WY*, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, (Chang YJ*). Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics. 11(6), 2594-2611, 2021-01. [JCR]　[WOS]
Hsu TS, Lin YL, Wang YA, Mo ST, Chi PY, Lai AC, Pan HY, (Chang YJ), Lai MZ. HIF-2α is indispensable for regulatory T cell function. Nature Communications. 11, 5005, 1-16, 2020-10. [JCR]　[WOS]
Tsai CH, Wu AC, Chiang BL, Yang YH, Hung SP, Su MW, (Chang YJ), Lee YL. CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children. Thorax. 75(9), 725-734, 2020-09. [JCR]　[WOS]
Lai YT, Chao HW, Lai AC, Lin SH, (Chang YJ)*, Huang YS*. CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. Journal of Biomedical Science. 27:52, 1-17, 2020-04. [JCR]　[WOS]
Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, (Chang YJ*). Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy. 75 (4), 818-830, 2020-04. [JCR]　[WOS]
Lai AC, Chi PY, Thio CL , Han YC, Kao HN, Hsieh HW, Gervay-Hague J*, (Chang YJ*). α-Lactosylceramide protects against iNKT-mediated murine airway hyperreactivity and liver injury through competitive inhibition of CD1d binding. Frontiers in Chemistry. 7(811), 1-12, 2019-11. [JCR]　[WOS]
Thio CL, Lai AC, Chi PY, Webster G, (Chang YJ*). Toll-like receptor 9–dependent interferon production prevents group 2 innate lymphoid cell–driven airway hyperreactivity. Journal of Allergy and Clinical Immunology. 144(3), 682-697, 2019-09. [JCR]　[WOS]
Chuang YT, Leung K, (Chang YJ), DeKruyff RH, Savage PB, Cruse R, Benoit C, Elewaut D, Baumgarth N, Umetsu DT. A natural killer T cell subset that protects against airway hyperreactivity. Journal of Allergy and Clinical Immunology. 143 (2), 565-576, 2019-02. [JCR]　[WOS]
Thio CL, Chi PY, Lai AC, (Chang YJ*). Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. Journal of Allergy and Clinical Immunology. 142(6), 1867-1883, 2018-12. [JCR]　[WOS]
Chen WY*, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, (Chang YJ*). IL-33/ST2 axis mediates the hyperplasia of intrarenal urothelium in obstructive renal injury. Experimental and Molecular Medicine. 50(4), 1-11, 2018-04. [JCR]　[WOS]
Hsieh WC, Hsu TS, (Chang YJ), Lai MZ. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nature Communications. 9(1), 1-15, 2018-01. [JCR]　[WOS]
Chen LY, Yang-Yen HF, Tsai CC, Thio CL, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, (Chang YJ), Chen YT, Yen JJ. Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. Journal of Investigative Dermatology. 137(4), 894-904, 2017-04. [JCR]　[WOS]
Lai YT, Su CK, Jiang ST, (Chang YJ), Lai AC, Huang YS. Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction. Journal of Neuroscience. 36(50), 12661-12676, 2016-12. [JCR]　[WOS]
Chen WY, (Chang YJ), Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL. Upregulation of Interleukin-33 in obstructive renal injury. Biochemical and Biophysical Research Communications. 473(4), 1026-1032, 2016-05. [JCR]　[WOS]
(Chang YJ*), Hsuan YC, Lai AC, Han YC, Hou DR*. Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4'-epi-C-Glycoside of KRN7000. Organic Letters. 18(4), 808-811, 2016-02. [JCR]　[WOS]
Ho KC, Chiang YJ, Lai AC, Liao NS, (Chang YJ), Yang-Yen HF, Yen JJ. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death & Disease. 5, e1518, 1-11, 2014-11. [JCR]　[WOS]
Yu S, Kim HY, (Chang YJ), DeKruyff RH, Umetsu DT. Innate lymphoid cells and asthma. Journal of Allergy and Clinical Immunology. 133(4), 943-950, 2014-04. [JCR]　[WOS]
Lin J, (Chang YJ), Yang WB, Yu AL, Wong CH. The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes. PLoS One. 9(4), e94040, 1-12, 2014-04. [JCR]　[WOS]
Huang JR, Tsai YC, (Chang YJ), Wu JC, Hung JT, Lin KH, Wong CH, Yu AL. alpha-Galactosylceramide but not phenyl-glycolipids induced NKT cell anergy and IL-33-mediated myeloid-derived suppressor cell accumulation via upregulation of egr2/3. Journal of Immunology. 192(4), 1972-1981, 2014-02. [JCR]　[WOS]
Kim HY, Lee HJ, (Chang YJ), Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nature Medicine. 20(1), 54-61, 2014-01. [JCR]　[WOS]
(Chang YJ*), DeKruyff RH, Umetsu DT*. The role of type 2 innate lymphoid cells in asthma. Journal of Leukocyte Biology. 94(5), 933-940, 2013-11. [JCR]　[WOS]
Albacker LA*, Chaudhary V*, (Chang YJ*), Kim HY*, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nature Medicine. 19(10), 1297-1304, 2013-10. [JCR]　[WOS]
Kim HY*, (Chang YJ*), Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. Journal of Allergy and Clinical Immunology. 132(2), 414-425, 2013-08. [JCR]　[WOS]
Kim HY*, (Chang YJ*), Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.129(1):216-27. Journal of Allergy and Clinical Immunology. 129(1), 216-227, 2012-01. [JCR]　[WOS]
Wu TN, Lin KH, (Chang YJ), Huang JR, Cheng JY, Yu AL, Wong CH. Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy. Proceedings of the National Academy of Sciences. 108(42), 17275-17280, 2011-10. [JCR]　[WOS]
(Chang YJ), Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nature Immunology. 12(7), 631-638, 2011-05. [JCR]　[WOS]
(Chang YJ), Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk B, Franck RW, Chen G, DeKruyff RH, Shimamura M, Illarionov P, Umetsu DT. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. Journal of Clinical Investigation. 121(1), 57-69, 2011-01. [JCR]　[WOS]
Albacker LA, Karisola P, (Chang YJ), Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. Journal of Immunology. 185(11), 6839-6849, 2010-12. [JCR]　[WOS]
(Chang YJ), Huang JR, Tsai YC, Hung JT, Wu D, Fujio M, Wong CH, Yu AL. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids. Proceedings of the National Academy of Sciences. 104(25), 10299-10304, 2007-06. [JCR]　[WOS]
(Chang YJ), Wu MS, Lin JT, Pestell RG, Blaser MJ, Chen CC. Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle. Cellular Microbiology. 8(11), 1740-1752, 2006-11. [JCR]　[WOS]
Chang YT, Wu MS, (Chang YJ), Chen CC, Lin YS, Hsieh T, Yang PC, Lin JT. Distinct gene expression profiles in gastric epithelial cells induced by different clinical isolates of Helicobacter pylori--implication of bacteria and host interaction in gastric carcinogenesis. Hepato-Gastroenterology. 53(70), 484-490, 2006-08. [JCR]　[WOS]
(Chang YJ), Wu MS, Lin JT, Chen CC. Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation. Journal of Immunology. 175(12), 8242-8252, 2005-12. [JCR]　[WOS]
(Chang YJ), Wu MS, Lin JT, Sheu BS, Muta T, Inoue H, Chen CC. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Molecular pharmacology. 66(6), 1465-1477, 2004-12. [JCR]　[WOS]
(Chang YJ), Liu CY, Chiang BL, Chao YC, Chen CC. Induction of IL-8 release in lung cells via activator protein-1 by recombinant baculovirus displaying severe acute respiratory syndrome-coronavirus spike proteins: identification of two functional regions. Journal of Immunology. 173(12), 7602-7614, 2004-12. [JCR]　[WOS]
Chen CC, Chow MP, Huang WC, Lin YC, (Chang YJ). Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Molecular Pharmacology. 66(3), 683-693, 2004-09. [JCR]　[WOS]
(Chang YJ), Holtzman MJ, Chen CC. Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1. Molecular Pharmacology. 65(3), 589-598, 2004-03. [JCR]　[WOS]
(Chang YJ), Holtzman MJ, Chen CC. Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway. Journal of Biological Chemistry,. 277(9), 7118-7126, 2002-03. [JCR]　[WOS]
Chen CC, Sun YT, Chen JJ, (Chang YJ). Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. Molecular Pharmacology. 59(3), 493-500, 2001-03. [JCR]　[WOS]