Research Findings
- Shi Jie#, Zhang Zijian#, Chen Hsin-Yi#, Yao Yingmeng, Ke Shanwen, Yu Kechun, Shi Jiangzhou, Xiao Xiangling, He Chuan, Xiang Bolin, Sun Yishuang, Gao Minling, Xing Xixin, Yu Haisheng, Wang Xiyong, Yuan Wei-Chien, Budiarto Bugi Ratno, Chen Shih-Yu, Zhang Tongcun, (Lee Yu-Ru)*, Zhu Haichuan*, Zhang Jinfang*. Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR T cell therapy. Molecular Therapy. , 2025-02-03. [JCR]
- He C#, Xing X#, Chen HY#, Gao M, Shi J, Xiang B, Xiao X, Sun Y, Yu H, Xu G, Yao Y, Xie Z, Xing Y, Budiarto BR, Chen SY, Gao Y, (Lee YR)*, Zhang J*. UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity. Molecular cell. 84(6), 1120-1138.e8, 2024. [JCR] [WOS]
- Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, (Lee YR), Wei W, Freeman GJ, Xie C, Zhang J. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications. 14(1), 2859, 2023. [JCR] [WOS]
- Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, (Lee YR), Pan L, Shaw RJ, Yuan J, Wei W. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.). 380(6652), 1372-1380, 2023. [JCR] [WOS]
- Zhang T, Xu D, Liu J, Wang M, Duan LJ, Liu M, Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, (Lee YR), Pan L, Kaelin WG Jr, Yuan J, Wei W. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nature cell biology. Jul 3., Jul 3.-Jul 3., 2023. [JCR] [WOS]
- Lee JD, Paulo JA, Posey RR, Mugoni V, Kong NR, Cheloni G, (Lee YR), Slack FJ, Tenen DG, Clohessy JG, Gygi SP, Pandolfi PP. Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia. Nature methods. 18(3), 293–302, 2021. [JCR] [WOS]
- Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, (Lee YR), Pandolfi PP. WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. The Journal of clinical investigation. 131(24), e140436-e140436, 2021. [JCR] [WOS]