Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 黃明經 Hwang, Ming-Jing

Journal 80

Liu Chih-Min, Shih Edward S.C., Chen Jhih-Yu, Huang Chih-Han, Wu I-Chien, Chen Pei-Fen, Higa Satoshi, Yagi Nobumori, Hu Yu-Feng, Hwang Ming-Jing, Chen Shih-Ann. Artificial Intelligence-Enabled Electrocardiogram Improves the Diagnosis and Prediction of Mortality in Patients With Pulmonary Hypertension. JACC: Asia. 2(3), 258-270, 2022. [JCR]
Yang Ching-Chun, Chang Chih-Hsu, Chen Heng-Li, Chou Ming-Chieh, Yang Ching-Jen, Jhou Ren-Shiang, Huang Er-Yi, Li Hung-Cheng, Suen Ching-Shu, Hwang Ming-Jing, Shih Chiaho. CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA. Cell Reports. 38(10), 110472, 2022. [JCR]　[WOS]
Hu Yu-Feng*, Wu Chih-Hsun, Lai Tsung-Ching, Chang Yu-Chan, (Hwang Ming-Jing), Chang Ting-Yung, Weng Ching-Hui, Chang Peter Mu-Hsin, Chen Che-Hong, Mochly-Rosen Daria, Huang Chi-Ying F., Chen Shih-Ann. ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867(5), 166088, 2021. [JCR]　[WOS]
Chang Chih-Shin, Liao Chun-Che, Liou An-Ting, Chou Yi-Chun, Yu Ya-Yen, Lin Chi-Yung, Lin Jen-Shiou, Suen Ching-Shu, (Hwang Ming-Jing), Shih Chiaho*. Novel Naturally Occurring Mutations of Enterovirus 71 Associated With Disease Severity. Frontiers in Microbiology. 11, 610568, 2021. [JCR]　[WOS]
Peng Hubert, Chiu Tzu-Yuan, Liang Yu-Jen, Lee Chia-Jen, Liu Chih-Syuan, Suen Ching-Shu, Yen Jeffrey J.-Y., Chen Hung-Ta, (Hwang Ming-Jing), Hussain M Mahmood, Yang Hsin-Chou, Yang-Yen Hsin-Fang. PRAP1 is a novel lipid binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport. Journal of Biological Chemistry. 296, 100052, 2021. [JCR]　[WOS]
Chang Kuan-Cheng, Hsieh Po-Hsin, Wu Mei-Yao, Wang Yu-Chen, Chen Jan-Yow, Tsai Fuu-Jen, Shih Edward S.C., (Hwang Ming-Jing), Huang Tzung-Chi. Usefulness of Machine Learning-Based Detection and Classification of Cardiac Arrhythmias With 12-Lead Electrocardiograms. Canadian Journal of Cardiology. 37(1), 94-104, 2021. [JCR]　[WOS]
Chang Kuan-Cheng*, Hsieh Po-Hsin, Wu Mei-Yao, Wang Yu-Chen, Wei Jung-Ting, Shih Edward S C, (Hwang Ming-Jing), Lin Wan-Ying, Lin Wan-Ting, Lee Kuan-Jung, Wang Ti-Hao. Usefulness of multi-labelling artificial intelligence in detecting rhythm disorders and acute ST-elevation myocardial infarction on 12-lead electrocardiogram. European Heart Journal - Digital Health. 2(2), 299-310, 2021. [JCR]　[WOS]
Huang Meng‐Sen, Chang Jen‐Hsuan, Lin Wen‐Ching, Cheng Yu‐Hsiang, Li Fu‐An, Suen Ching‐Shu, (Hwang Ming‐Jing), Chang Chung‐ke, Mou Kurt Yun. SLC38A2 Overexpression Induces a Cancer-like Metabolic Profile and Cooperates with SLC1A5 in Pan-cancer Prognosis. Chemistry – An Asian Journal. 15(22), 3861-3872, 2020-11. [JCR]　[WOS]
Sudhakar Janaki N., Lu Hsueh-Han, Chiang Hung-Yu, Suen Ching-Shu, (Hwang Ming-Jing), Wu Sung-Yu, Shen Chia-Ning, Chang Yao-Ming, Li Fu-An, Liu Fu-Tong, Shui Jr-Wen. Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas. Nature Communications. 11(1), 4286, 2020-08. [JCR]　[WOS]
Chen Tsai-Min, Huang Chih-Han, Shih Edward S.C., Hu Yu-Feng, (Hwang Ming-Jing)*. Detection and Classification of Cardiac Arrhythmias by a Challenge-Best Deep Learning Neural Network Model. iScience. 23(3) ,100886, 2020-03. [JCR]　[WOS]
Huang HC, Cai BH, Suen CS, Lee HY, (Hwang MJ), Liu FT, Kannagi R. BGN/TLR4/NF-κB Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells. CELLS. 9(2), 397, 2020-02. [JCR]　[WOS]
Wu CH, (Hwang MJ)*. Risk Stratification for Lung Adenocarcinoma on EGFR and TP53 Mutation Status, Chemotherapy and PD-L1 Immunotherapy. CANCER MEDICINE. 8(13), 5850-5861, 2019-08. [JCR]　[WOS]
Chin DC, Rajendran SK, Suen CS, Chien CY, (Hwang MJ), Hsu CH, Xu X, Lai ZX, Yeh KW*. Plant cytosolic ascorbate peroxidase with dual catalytic activity modulates abiotic stress tolerance. iScience. 16, 31–49, 2019-06. [JCR]　[WOS]
Huang HC, Chao CC, Wu PH, Chung HY, Lee HY, Suen CS, (Hwang MJ), Cai BH, Kannagi R*. Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1862(2), 173-183, 2019-02. [JCR]　[WOS]
Sun CT, Chiang AWT, (Hwang M-J)*. A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters. SCIENTIFIC REPORTS. 7, 14210, 2017-10. [JCR]　[WOS]
Liu CS, Yang-Yen HF, Suen CS, (Hwang MJ), Yen JJY*. Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. SCIENTIFIC REPORTS. 7, 4613, 2017-07. [JCR]　[WOS]
Chang SM, Christian W, Wu MH, Chen TL, Lin YW, Suen CS, Pidugu HB, Detroja D, Shah A, Hwang MJ, Su TL, Lee TC*. Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 127, 235-249, 2017-02. [JCR]　[WOS]
Austin WT Chiang, Walt YL Wu, Ting Wang, Ming-Jing Hwang*. Identification of Entry Factors Involved in Hepatitis C Virus Infection Based on Host-Mimicking Short Linear Motifs. PLOS COMPUTATIONAL BIOLOGY. 13(1), e1005368, 2017-01. [JCR]　[WOS]
Hsu CH, Chiang AW, (Hwang MJ)*, Liao BY*. Proteins with highly evolvable domain architectures are non-essential but highly retained. Molecular biology and evolution. 33(5), 1219-1230, 2016. [JCR]　[WOS]
Chuang HY, Suen CS, Hwang MJ, Roffler SR*. Toward reducing immunogenicity of enzyme replacement therapy: altering the specificity of human β-glucuronidase to compensate for α-iduronidase deficiency. PROTEIN ENGINEERING DESIGN & SELECTION. 28(11), 519-529, 2015-11. [JCR]　[WOS]
Shih ES, Hwang MJ*. NPPD: A Protein-Protein Docking Scoring Function Based on Dyadic Differences in Networks of Hydrophobic and Hydrophilic Amino Acid Residues. Biology. 4(2), 282-297, 2015-03. [JCR]
Cheng YC, Chen PH, Chiang HY, Suen CS, Hwang MJ, Lin TY, Yang HC, Lin WC, Lai PL, Shieh SY*. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death & Disease. 6, e1584, 2015-01. [JCR]　[WOS]
Xie ZR, (Hwang MJ)*. Methods for predicting protein-ligand binding sites. Methods in molecular biology (Clifton, N.J.). 1215, 383-398, 2015. [JCR]
Yu-Chiau Shyu*, Tung-Liang Lee, Xin Chen, Pang-Hung Hsu, Shau-Ching Wen, Yi-Wei Liaw, Chi-Huan Lu,Po-Yen Hsu, Mu-Jie Lu, JauLang Hwang, Ming-Daw Tsai, Ming-Jing Hwang, Jim-Ray Chen and Che-Kun James Shen*. Tight Regulation of a Timed Nuclear Import Wave of EKLF by PKCθ and FOE during Pro-E to Baso-E Transition. DEVELOPMENTAL CELL. 28(4), 409-422, 2014-02. [JCR]　[WOS]
Austin W.T. Chiang, Wei-Chung Liu, Pep Charusanti and Ming-Jing Hwang*. Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters. BMC Systems Biology. 8, 4, 2014-01. [JCR]　[WOS]
Austin W. T. Chiang, Grace T. W. Shaw, Ming-Jing Hwang*. Partitioning the Human Transcriptome Using HKera, a Novel Classifier of Housekeeping and Tissue-Specific Genes. PLoS One. 8(12), e83040, 2013-12. [JCR]　[WOS]
Chiang WT, Hwang MJ*. A computational pipeline for identifying kinetic motifs to aid in the design and improvement of synthetic gene circuits. BMC BIOINFORMATICS. 14(Suppl 16), S5, 2013-10. [JCR]　[WOS]
Hsu CH, Chen CK, Hwang MJ*. The architectural design of networks of protein domain architectures. Biology Letters. 9(4), 20130268, 2013-06. [JCR]　[WOS]
Xie ZR, Liu CK. Hsiao FC, Yao A, Hwang MJ*. LISE: a server using ligand-interacting and site-enriched protein triangles for prediction of ligand-binding sites. NUCLEIC ACIDS RESEARCH. 41(W1), W292-W296, 2013-04. [JCR]　[WOS]
Shih ES, Hwang MJ*. A critical assessment of information-guided protein-protein docking predictions. Molecular and cellular proteomics. 12(3), 679-686, 2013-03. [JCR]　[WOS]
Xie ZR, Hwang MJ*. Ligand binding site prediction using ligand-interacting and binding site-enriched protein triangles. BIOINFORMATICS. 28(12), 1579-1585, 2012-04. [JCR]　[WOS]
Minucci A*, Moradkhani K, Hwang MJ. Zuppi C, Giardina B, Capoluongo E.*. Glucose-6-phosphate dehydrogenase (G6PD) mutations database: Review of the “old” and update of the new mutations. Blood Cells Molecules and Diseases. 48(3), 154-165, 2012-03. [JCR]　[WOS]
Shih ES,( Hwang MJ*). On the use of distance constraints in protein-protein docking computations. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 80(1), 194-205, 2012-01. [JCR]　[WOS]
Grace T.W. Shaw, Edward S.C. Shih, Chun-Houh Chen, Ming-Jing Hwang*. Preservation of Ranking Order in the Expression of Human Housekeeping Genes. PLoS One. 6(12), e29314, 2011-12. [JCR]　[WOS]
Chung KM, Huang CH, Cheng JH, Tsai CH, Suen CH, (Hwang MJ), Chen X*. Proline in transmembrane domain of type II protein DPP-IV governs its translocation behavior through endoplasmic reticulum. BIOCHEMISTRY. 50(37), 7909-7918, 2011-09. [JCR]　[WOS]
Huang CH, Suen CS, Lin CT, Chien CH, Lee HY, Chung KM, Tsai TY, Jiaang WT, (Hwang MJ), Chen X.*. Cleavage-site Specificity of Prolyl Endopeptidase FAP Investigated with a Full-Length Protein Substrate. JOURNAL OF BIOCHEMISTRY. 149(6), 685-692, 2011-06. [JCR]　[WOS]
Chung, K.M., Cheng, J.H., Suen, C.S., Huang, C.H., Tsai, C.H., Huang, L.H., Chen, Y.R., Wang, A.H., Hwang, M.-J., Chen, X.*. The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities. PROTEIN SCIENCE. 19, 1627-1638, 2010-09. [JCR]　[WOS]
Xie, Z.R., Hwang, M.-J.*. An interaction-motif-based scoring function for protein-ligand docking. BMC Bioinformatics. 11, 298, 2010-06. [JCR]　[WOS]
Lin, Y.-M., Wu, S.-J., Chang, T.-W., Wang, C.-F., Suen, C.-S., Hwang, M.-J., Chang, M.-D., Chen, Y.-T., Liao, Y.-D.*. Outer membrane protein I of pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. J. Biol. Chem.. 285(12), 8985-8994, 2010-03. [JCR]　[WOS]
Hwang, H.-W., Lee, J.-R., Chou, K.-U., Suen, C.-S., Hwang, M.-J., Chen, C., Shieh*, R.-C., Chau, L.-Y.*. Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum. J. Biol. Chem.. 284(34), 22672-22679, 2009-08. [JCR]　[WOS]
Lin, W.-H., Liu, W.-c.*, Hwang, M.-J.*. Topological and organizational properties of the products of house-keeping and tissue-specific genes in protein-protein interaction networks. BMC Systems Biology. 3, 32, 2009-03. [JCR]　[WOS]
Chen, H.W., Liu, W.-c.*, Davis, A.J., Jordan, F., Hwang, M.-J., Shao, K.T. Network position of hosts in food webs and their parasite diversity. OIKOS. 117, 1847-1855, 2008-12. [JCR]　[WOS]
W.-c. Liu, W.-h. Lin, A. J. Davis, F. Jorden, H.-t. Yang and M. J. Hwang. A network perspective on the topological importance of enzymes and their phylogenetic conservation. BMC Bioinformatics. 8, 121, 2007. [JCR]　[WOS]
H. T. Yang, C. P. Hsu and M.J. Hwang. An analytical rate expression for the kinetics of gene transcription mediated by dimeric transcription factors. J Biochem. 142(2), 135-144, 2007. [JCR]　[WOS]
Z. R. Xie, H.-t. Yang, W.-c. Liu and M. J. Hwang. The role of microRNA in the delayed negative feedback regulation of gene expression. Biochemical and Biophysical Research Communications. 358, 722-726, 2007. [JCR]　[WOS]
S. Y. Pao, W. L. Lin and M. J. Hwang. In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues. BMC Genomics. 7, 86, 2006. [JCR]　[WOS]
E. S. Shih, R. C. Gan and M. J. Hwang. OPAAS: a web server for optimal, permuted, and other alternative alignments of protein structures. Nucleic Acids Res. 34(Web Server issue), W95-W98, 2006. [JCR]　[WOS]
D. T. Chang, Y. Z. Weng, J. H. Lin, M. J. Hwang and Y. J. Oyang. Protemot: prediction of protein binding sites with automatically extracted geometrical templates. Nucleic Acids Res. 34(Web Server issue), W303-W309, 2006. [JCR]　[WOS]
S.-L. Wang, C.-M. Chen, M. J. Hwang. Classification of Protein 3D Folds by Hidden Markov Learning on Sequences of Structural Alphabets. Proceedings of The Third Asia-Pacific Bioinformatics Conference. 65-72, 2005.
E. S. C. Shih, M. J. Hwang. Alternative Alignments from Comparison of Protein Structures. Proteins. 56, 519-527, 2004. [JCR]　[WOS]
Y. Y. Kao, H. L. Lai, M. J. Hwang and Y. Chern. An Important functional role of the N terminus domain of type VI adenylyl cyclase (ACVI) in Gia-mediated inhibition. J Biol Chem. 279, 34440-34448, 2004. [JCR]　[WOS]
I. Y. Lee, T. T. Soong, J. M. Ho and M. J. Hwang. Derivation and Analysis of Fragment Libraries of Protein Structures. Fourth IEEE Symposium on Bioinformatics and Bioengineering. 516-521, 2004.
T. T. Soong, M. J. Hwang and C. M. Chen. Discovery of Recurrent Structural Motifs for Approximating Three-Dimensional Protein Structures. Journal of the Chinese Chemical Society. 51, 1107-1114, 2004. [JCR]　[WOS]
S. R. Shih, C. Chiang, T. C. Chen, C. N. Wu, J. T. Hsu, J. C. Lee, M. J. Hwang, M. L. Li, G. W. Chen and M. S. Ho. Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities. J Biomed Sci. 11, 239-248, 2004. [JCR]　[WOS]
B. Y. Liao, Y. J. Chang, J. M. Ho and M. J. Hwang. The UniMarker (UM) Method for Synteny Mapping of Large Genomes. Bioinformatics. 20, 3156-3165, 2004. [JCR]　[WOS]
C. S. Yeh, F. M. Chen, J. Y. Wang, T. L. Cheng, M. J. Hwang and W. S. Tzou. Directional shape complementarity at the protein-DNA interface. J Mol Recognit. 16, 213-222, 2003. [JCR]　[WOS]
E. S. Shih, M. J. Hwang. Protein structure comparison by probability-based matching of secondary structure elements. Bioinformatics. 19, 735-741, 2003. [JCR]　[WOS]
M. C. Chen, M. J. Hwang, Y. C. Chou, W. H. Chen, G. Cheng, H. Nakano, T. Y. Luh, S. C. Mai and S. L. Hsieh. The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem. 278, 16073-16081, 2003. [JCR]　[WOS]
J. M. Yang, C. H. Tsai, M. J. Hwang, H. K. Tsai, J. K. Hwang and C. Y. Kao. GEM: a Gaussian Evolutionary Method for predicting protein side-chain conformations. Protein Sci. 11, 1897-1907, 2002. [JCR]　[WOS]
T. H. Lin, H. L. Lai, Y. Y. Kao, C. N. Sun, M. J. Hwang and Y. Chern. Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains. J Biol Chem. 277, 15721-15728, 2002. [JCR]　[WOS]
L. Y. Chen, S. H. Lu, E. S. Shih and M. J. Hwang. Single nucleotide polymorphism mapping using genome-wide unique sequences. Genome Res. 12, 1106-1111, 2002. [JCR]　[WOS]
C. S. Ewig, R. Berry, U. Dinur, J. R. Hill, M. J. Hwang, H. Li, C. Liang, J. Maple, Z. Peng, T. P. Stockfisch, T. S. Thacher, L. Yan, X. Ni and A. T. Hagler. Derivation of class II force fields. VIII. Derivation of a general quantum mechanical force field for organic compounds. J Comput Chem. 22, 1782-1800, 2001. [JCR]　[WOS]
P. L. Yao, M. J. Hwang, Y. M. Chen and K. W. Yeh. Site-directed mutagenesis evidence for a negatively charged trypsin inhibitory loop in sweet potato sporamin. FEBS Lett. 496, 134-138, 2001. [JCR]　[WOS]
C. L. Liu, C. C. Tsai, S. C. Lin, L. I. Wang, C. I. Hsu, M. J. Hwang and J. Y. Lin. Primary structure and function analysis of the Abrus precatorius agglutinin A chain by site-directed mutagenesis. Pro(199) Of amphiphilic alpha-helix H impairs protein synthesis inhibitory activity. J Biol Chem. 275, 1897-1901, 2000. [JCR]　[WOS]
Y. S. Cheng, T. K. Tang and M. J. Hwang. Amino Acid Conservation and Clinical Severity of Human Glucose-6-Phosphate Dehydrogenase Mutations. J. Biomed. Sci.. 6, 106-114, 1999. [JCR]　[WOS]
M. J. Hwang, P. Y. Chu, J. C. Chen and I. Chao. Conformational Analysis of Three Pyrophosphate Model Species: Diphosphate, Methyl Diphosphate, and Triphosphate. J. Comput. Chem. 20, 1702-1715, 1999. [JCR]　[WOS]
W. S. Tzou, M. J. Hwang. Modeling helix-turn-helix protein-induced DNA bending with knowledge-based distance restraints. Biophys J. 77, 1191-1205, 1999. [JCR]　[WOS]
P. K. Yang, W. S. Tzou and M. J. Hwang. Restraint-driven formation of alpha-helical coiled coils in molecular dynamics simulations. Biopolymers. 50, 667-677, 1999. [JCR]　[WOS]
J. W. Chen, Y. L. Luo, M. J. Hwang, F. C. Peng and K. H. Ling. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 274, 34916-34923, 1999. [JCR]　[WOS]
H. L. Lai, T. H. Lin, Y. Y. Kao, W. J. Lin, M. J. Hwang and Y. Chern. The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C. Mol Pharmacol. 56, 644-650, 1999. [JCR]　[WOS]
J. R. Maple, M. J. Hwang, K. J. Jalkanen, T. P. Stockfisch, A. T. Hagler. Derivation of Class II Force Fields. 5. Quantum Force Field for Amides, Peptides, and Related Compounds. J. Comput. Chem.. 19, 430-458, 1998. [JCR]　[WOS]
M. J. Hwang, X. Ni, M. Waldman, C. S. Ewig and A. T. Hagler. Derivation of class II force fields. VI. Carbohydrate compounds and anomeric effects. Biopolymers. 45, 435-468, 1998. [JCR]　[WOS]
C. Y. Lee, P. K. Yang, W. S. Tzou and M. J. Hwang. Estimates of relative binding free energies for HIV protease inhibitors using different levels of approximations. Protein Engineering. 11, 429-437, 1998. [JCR]　[WOS]
P. Y. Chu and M. J. Hwang. New insights for dinucleotide backbone binding in conserved C5'-H . . . O hydrogen bonds. J Mol Biol. 279, 695-701, 1998. [JCR]　[WOS]
P. Y. Chu and M. J. Hwang. New insights for dinucleotide backbone binding in conserved C5'-H...O hydrogen bonds. J Mol Biol. 279, 695-701, 1998. [JCR]　[WOS]
W. J. Lin, M. J. Hwang. VHMPT: a graphical viewer and editor for helical membrane protein topologies. Bioinformatics. 14, 866-868, 1998. [JCR]　[WOS]
W. S. Tzou, M. J. Hwang. A model for Fis N-terminus, Fis-invertase recognition. FEBS Lett. 401, 1月5日, 1997. [JCR]　[WOS]
Z. Peng, C. S. Ewig, M. J. Hwang, M. Waldman and A. T. Hagler. Derivation of Clase II Force Fields. 4. van der Waals Parameters of Alkali Metal Cations and Halide Anions. Journal of Physical Chemistry A. 101, 7243-7252, 1997. [JCR]　[WOS]
W. S. Tzou, M.J. Hwang. Introduction to Protein Structure Predictions. The Chinese Chem. Soc., Taiwan China. 55, 101-109, 1997.
P. K. Yang, C. Y. Lee and M. J. Hwang. Shaker pore structure as predicted by annealed atomic simulation using symmetry and novel geometric restraints. Biophys J. 72, 2479-2489, 1997. [JCR]　[WOS]

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