Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 謝小燕 Shieh, Sheau-Yann

Journal 37

Cheng YC, Acedera JD, Li YJ, Shieh SY. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis. Cell death and differentiation. OAP, May 7, 2024. [JCR]　[WOS]
Chowdhury MAN, Wang SW, Suen CS, Hwang MJ, Hsueh YA, Shieh SY. JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability. Cell death & disease. 13(7), 619, 2022. [JCR]　[WOS]
Cheng YC, Chiang HY, Cheng SJ, Chang HW, Li YJ, (Shieh SY)*. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. CELL DEATH & DISEASE. 11(12), 1046, 2020-12. [JCR]　[WOS]
Hsu PC, Gopinath RK, Hsueh YA, Shieh SY. CHK2-mediated regulation of PARP1 in oxidative DNA damage response. Oncogene. 38(8), 1166–1182, 2019-02. [JCR]　[WOS]
Cheng YC, Shieh SY. Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Proceedings of the National Academy of Sciences of the United States of America. 115(21), 5546-5551, 2018. [JCR]　[WOS]
Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y. CK1alpha ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proceedings of the National Academy of Sciences of the United States of America. 114(38), E8035-E8044, 2017. [JCR]　[WOS]
Yu ZC, Huang YF, Shieh SY. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic acids research. 44(3), 1133-1150, 2016. [JCR]　[WOS]
Cheng YC, Chen PH, Chiang HY, Suen CS, Hwang MJ, Lin TY, Yang HC, Lin WC, Lai PL, Shieh SY. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death & Disease. 6, e1584, 2015. [JCR]　[WOS]
Yeh CW, Yu ZC, Chen PH, Cheng YC, Shieh SY. Phosphorylation at Threonine 288 by Cell Cycle Checkpoint Kinase 2 (CHK2) Controls Human Monopolar Spindle 1 (Mps1) Kinetochore Localization. The Journal of biological chemistry. 289(22), 15319-15327, 2014. [JCR]　[WOS]
Cheng YC, Lin TY, Shieh SY. Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proceedings of the National Academy of Sciences of the United States of America. 110(15), 5993-5998, 2013. [JCR]　[WOS]
Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, Lai PL, (Shieh SY*). Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. ONCOGENE. 31(27), 3287-3297, 2012-07. [JCR]　[WOS]
Park JH, Smith RJ, Shieh SY, Roeder RG. The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability. JOURNAL OF BIOLOGICAL CHEMISTRY. 286(13), 10911-10917, 2011-04. [JCR]　[WOS]
Lai MC, Chang WC, (Shieh SY), Tarn WY*. DDX3 regulates cell growth through translational control of cyclin E1. Molecular and cellular biology. 30(22), 5444-5453, 2010-11. [JCR]　[WOS]
(Shieh SY*). Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells. CELL CYCLE. 9(14), 2712, 2010-07. [JCR]　[WOS]
Hsu FF, Lin TY, Chen JY, (Shieh SY*). p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control. Oncogene. 29(19), 2864-2876, 2010-05. [JCR]　[WOS]
Te-Ping Sun, Sheau-Yann Shieh*. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. Oncogene. 28(18),1971-1981, 2009-05. [JCR]　[WOS]
Y. H. Yeh, Y. F. Huang, T. Y Lin and S. Y. Shieh. The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1. Oncogene. 28(10), 1366-1378, 2009-03. [JCR]　[WOS]
Kuo PC, Tsao YP, Chang HW, Chen PH, Huang CW, Lin ST, Weng YT, Tsai TC, Shieh SY, Chen SL. Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor. Cancer research. 69(23), 8877-8885, 2009. [JCR]　[WOS]
Y. F. Huang, M. D. T. Chang and S. Y. Shieh. TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. Mol. Cell. Biol.. 29, 2935-2944, 2009. [JCR]　[WOS]
Wen-Cheng Chou, Hui-Chun Wang, Fen-Hwa Wong, Shian-ling Ding, Pei-Ei Wu, Sheau-Yann Shieh*, Chen-Yang Shen*. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J.. 27, 3140-3150, 2008-12. [JCR]　[WOS]
Y. H. Ou, P. H. Chung, F. F. Hsu, T. P. Sun, W. Y. Chang and S. Y. Shieh. The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J. 26(17), 3968-3980, 2007. [JCR]　[WOS]
H. C. Wang, W. C. Chou, S. Y. Shieh and C. Y. Shen. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 66, 1391-1400, 2006. [JCR]　[WOS]
Y. H. Ou, P. H. Chung, T. P. Sun and S. Y. Shieh. p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation. Mol Biol Cell. 16, 1684-1695, 2005. [JCR]　[WOS]
J. H. Wei, Y. F. Chou, Y. H. Ou, Y. S. Ye, S. W. Tyan, T. P. Sun, C. Y. Shen and S. Y. Shieh. TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. J Biol Chem. 280, 7748-7757, 2005. [JCR]　[WOS]
V. Gottifredi, S. Shieh, Y. Taya and C. Prives. p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proceedings of the National Academy of Sciences of the United States of America. 98, 1036-1041, 2001. [JCR]　[WOS]
V. Gottifredi, O. Karni-Schmidt, S. S. Shieh and C. Prives. p53 down-regulates CHK1 through p21 and the retinoblastoma protein. Mol Cell Biol. 21, 1066-1076, 2001. [JCR]　[WOS]
V. Gottifredi, S. Y. Shieh and C. Prives. Regulation of p53 after different forms of stress and at different cell cycle stages. Cold Spring Harbor symposia on quantitative biology. 65, 483-488, 2000. [JCR]　[WOS]
S. Y. Shieh, J. Ahn, K. Tamai, Y. Taya and C. Prives. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes & Development. 14, 289-300, 2000. [JCR]　[WOS]
R. S. Tibbetts, K. M. Brumbaugh, J. M. Williams, J. N. Sarkaria, W. A. Cliby, S. Y. Shieh, Y. Taya, C. Prives and R. T. Abraham. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes & Development. 13, 152-157, 1999. [JCR]　[WOS]
S. Y. Shieh, Y. Taya and C. Prives. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. Embo J. 18, 1815-1823, 1999. [JCR]　[WOS]
E. de Stanchina, M. E. McCurrach, F. Zindy, S. Y. Shieh, G. Ferbeyre, A. V. Samuelson, C. Prives, M. F. Roussel, C. J. Sherr and S. W. Lowe. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes & Development. 12, 2434-2442, 1998. [JCR]　[WOS]
S. Banin, L. Moyal, S. Shieh, Y. Taya, C. W. Anderson, L. Chessa, N. I. Smorodinsky, C. Prives, Y. Reiss, Y. Shiloh and Y. Ziv. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281, 1674-1677, 1998. [JCR]　[WOS]
S. Y. Shieh, M. Ikeda, Y. Taya and C. Prives. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91, 325-334, 1997. [JCR]　[WOS]
L. J. Ko, S. Y. Shieh, X. Chen, L. Jayaraman, K. Tamai, Y. Taya, C. Prives and Z. Q. Pan. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol. 17, 7220-7229, 1997. [JCR]　[WOS]
Shieh SY, Stellrecht CM, Tsai MJ. Molecular characterization of the rat insulin enhancer-binding complex 3b2. Cloning of a binding factor with putative helicase motifs. The Journal of biological chemistry. 270(37), 21503-8, 1995. [JCR]　[WOS]
Robinson GL, Peshavaria M, Henderson E, Shieh SY, Tsai MJ, Teitelman G, Stein R. Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription. The Journal of biological chemistry. 269(4), 2452-60, 1994. [JCR]　[WOS]
Shieh SY, Tsai MJ. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. The Journal of biological chemistry. 266(25), 16708-14, 1991. [JCR]　[WOS]

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