生命組研究成果
期刊 17
- Lim Khai Lone, Chowdhury Kaushik, Hung Yu-Jen, Lai Ben Shih-Lei. IFN-γ-Dependent Macrophage Reprogramming Coordinates Inflammatory Resolution and Matrix Remodeling in Heart Regeneration. BioRxiv. 712551, 712551, 2026-03-18.
- Lin S, Schichines D, Hsu HM, Hung YL, Chowdhury K, Lin IT, Wang CJ, Tsai MJ, Liu ZY, Yang KC, Lai SB, Chen BC, Heald R. A modular tissue-clearing framework integrated with light-field microscopy enables rapid volumetric phenotyping of cardiac tissue. Research square. rs.3, rs-8566379, 2026.
- Rouf MA, Kurekci GK, Zhang S, Vanier SL, Kamel SM, Lee AN, Yang RB, Lai SL, Marin-Juez R. Developmental single-cell atlas of coronary vessel growth and cardiomyocyte interaction in zebrafish. Development (Cambridge, England). 153(2), dev20506, 2026.
- Chowdhury K, Huang CL, Lin IT, Hung YJ, Lim KL, Liu HW, Wei KH, Yang KC, Chang YM, Lai BS. Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka. Proceedings of the National Academy of Sciences of the United States of America. 123(16), e2524705123, 2026.
- Mintcheva J, Tseng TL, Goumenaki P, Neuschulz A, Senoussi A, Lelek S, Lim KL, Ming Z, Schafer R, Hnatiuk A, Ninov N, Beisaw A, McGrail M, Lai SB, Panakova D, Stainier DYR, Junker JP. In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart. Nature communications. 17(1), 4073, 2026.
- Lee Ann Nee, Wei Ke-Hsuan, Chowdhury Kaushik, Rouf Muhammad Abdul, Chu An-Ju, Hung Yu-Jen, Tsao Ku-Chi, Chen Yan-Ting, Lin Yuh-Charn, Chang Yao-Ming, Marín-Juez Rubén, Yang Ruey-Bing, Lai Shih-Lei (Ben). Scube2 Modulates Coronary Vessel Formation during Cardiac Growth and Regeneration in Zebrafish. BioRxiv. 695032, 695032, 2025-12-19.
- Constanty F, Wu B, Wei KH, Lin IT, Dallmann J, Guenther S, Lautenschlaeger T, Priya R, Lai SL, Stainier DYR, Beisaw A. Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration. Nature communications. 16(1), 3823, 2025.
- Tsai YW, Tseng YS, Wu YS, Song WL, You MY, Hsu YC, Chen WP, Huang WH, Chng JC, Lim CL, Wei KH, Ben Lai SL, Lee WC, Yang KC. N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic beta-Catenin signaling in cardiomyocytes. Nature communications. 16(1), 896, 2025. [JCR] [WOS]
- Wang YC, Wu PH, Ting WC, Wang YF, Yang MH, Su TH, Su JY, Sun HI, Huang WM, Tsai PL, Wernig G, Ho PC, Wang L, Wu CT, Chang YL, Chen TC, Meng TC, Chang YM, Lai SL, Li CW, Ko TM, Yang KC, Chang YJ, Chern Y, Kuo MC, Huang YT, Tzeng YS, Tang JL, Chen SY. Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells. Nature communications. 16(1), 5600, 2025. [JCR] [WOS]
- Lai SB, Hung YJ, Marin-Juez R. When the heart calls for help: Clusterin reprograms immunity to enable regeneration. Cell stem cell. 32(12), 1793-1795, 2025. [JCR] [WOS]
- Wei Ke-Hsuan, Lin I-Ting, Chowdhury Kaushik, Lim Khai Lone, Liu Kuan-Ting, Ko Tai-Ming, Chang Yao-Ming, Yang Kai-Chien, Lai Shih-Lei (Ben). Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration. eLife. 12, e84679, 2023-07. [JCR] [WOS]
- Chowdhury Kaushik, Lin Shi, Lai Shih-Lei. Comparative Study in Zebrafish and Medaka Unravels the Mechanisms of Tissue Regeneration. Frontiers in Ecology and Evolution. 10, 1, 2022. [JCR] [WOS]
- Chowdhury K, Lai SL, Marin-Juez R. Modulation of VEGFA Signaling During Heart Regeneration in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2475, 297-312, 2022. [JCR]
- Tsao KC, Lin YC, Chen YT, Lai SL, Yang RB. Zebrafish scube1 and scube2 cooperate in promoting Vegfa signaling during embryonic vascularization. Cardiovascular research. cvab, 125, 2022. [JCR] [WOS]
- Tsedeke AT, Allanki S, Gentile A, Jimenez-Amilburu V, Rasouli SJ, Guenther S, Lai SL, Stainier DYR, Marin-Juez R. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Developmental biology. 476, 259-271, 2021. [JCR] [WOS]
- El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Gunther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR. Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751), 193-197, 2019-04. [JCR] [WOS]
- Lai SL, Marin-Juez R, Stainier DYR. Immune responses in cardiac repair and regeneration: a comparative point of view. Cellular and molecular life sciences : CMLS. 76(7), 1365-1380, 2019-04. [JCR] [WOS]