生命組研究成果
期刊 21
- Wang Yi-Chuan, Wu Ping-Hsun, Ting Wen-Chieh, Wang Yi-Fu, Yang Ming-Han, Su Tung-Hung, Su Jia-Ying, Sun Hsun-I, Huang Wei-Min, Tsai Pei-Ling, Wernig Gerlinde, Ho Ping-Chih, Wang Limei, Wu Chen-Tu, Chang Yih-Leong, Chen Tseng-Cheng, Meng Tzu-Ching, Chang Yao-Ming, Lai Shih-Lei, Li Chia-Wei, Ko Tai-Ming, Yang Kai-Chien, Chang Ya-Jen, Chern Yijuang, Kuo Mei-Chuan, Huang Yen-Tsung, Tzeng Yi-Shiuan, Tang Jih-Luh, Chen Shih-Yu. Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells. Nature Communications. 16(1), 5600, 2025-07-01. [JCR]
- Shi Jie, Zhang Zijian, Chen Hsin-Yi, Yao Yingmeng, Ke Shanwen, Yu Kechun, Shi Jiangzhou, Xiao Xiangling, He Chuan, Xiang Bolin, Sun Yishuang, Gao Minling, Xing Xixin, Yu Haisheng, Wang Xiyong, Yuan Wei-Chien, Budiarto Bugi Ratno, Chen Shih-Yu, Zhang Tongcun, Lee Yu-Ru, Zhu Haichuan, Zhang Jinfang. Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy. Molecular Therapy. 33(3), 1073-1090, 2025-03. [JCR]
- Chien Y, Wu YR, Chen CY, Yang YP, Ching LJ, Wang BX, Chang WC, Chiang IH, Su P, (Chen SY), Lin WC, Wang IC, Lin TC, Chen SJ, Chiou SH. Identifying Multiomic Signatures of X-Linked Retinoschisis-Derived Retinal Organoids and Mice Harboring Patient-Specific Mutation Using Spatiotemporal Single-Cell Transcriptomics. ADVANCED SCIENCE. e2405818, e2405818, 2024-11. [JCR] [WOS]
- Mindaye SA, Chen WH, Lin SC, Chen YC, Abdelaziz MA, Tzeng YS, Shih AC, (Chen SY), Yang SB, Chen CC. Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain. Cell reports. 43(11), 114946, 2024-11. [JCR] [WOS]
- Alessio Bevilacqua, Fabien Franco, Ya-Ting Lu, Nabil Rahiman, Kung-Chi Kao, Yu-Ming Chuang, Yanan Zhu, Werner Held, Xin Xie, Kristin C Gunsalus, Zhengtao Xiao, (Shih-Yu Chen), Ping-Chih Ho. PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8+ T cells. SCIENCE IMMUNOLOGY. 9(8), eadn2717, 2024-08. [JCR] [WOS]
- Chung Kuei-Pin, Su Jia-Ying, Wang Yi-Fu, Budiarto Bugi Ratno, Yeh Yu-Chang, Cheng Jui-Chen, Keng Li-Ta, Chen Yi-Jung, Lu Ya-Ting, Juan Yi-Hsiu, Nakahira Kiichi, Ruan Sheng-Yuan, Chien Jung-Yien, Chang Hou-Tai, Jerng Jih-Shuin, Huang Yen-Tsung, (Chen Shih-Yu)*, Yu Chong-Jen*. Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness. Frontiers in Immunology. 15, 1334882, 2024-02. [JCR] [WOS]
- Siew Jian Jing, Chen Hui-Mei, Chiu Feng-Lan, Lee Chia-Wei, Chang Yao-Ming, Chen Hung-Lin, Nguyen Thi Ngoc Anh, Liao Hung-Ting, Liu Mengyu, Hagar Hsiao-Tien, Sun Yung-Chen, Lai Hsing-Lin, Kuo Min-Hao, Blum David, Buée Luc, Jin Lee-Way, (Chen Shih-Yu), Ko Tai-Ming, Huang Jie-Rong, Kuo Hung-Chih, Liu Fu-Tong, Chern Yijuang. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. Journal of Clinical Investigation. 134(2), e165523, 2024-01. [JCR] [WOS]
- Hong Shiao-Ya, Lu Ya-Ting, Chen Shih-Yu, Hsu Chiung-Fang, Lu Yi-Chun, Wang Cheng-Yi, Huang Kun-Lun. Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis. Cell Death & Disease. 14(6), 352, 2023-06-08. [JCR] [WOS]
- Cui Lu, Fang Zhuoqing, De Souza Cristabelle Madona, Lerbs Tristan, Guan Yuan, Li Irene, Charu Vivek, Chen Shih-Yu, Weissman Irving, Wernig Gerlinde. Innate immune cell activation causes lung fibrosis in a humanized model of long COVID. Proceedings of the National Academy of Sciences. 120(10), e2217199120, 2023-02-27. [JCR] [WOS]
- Huang Hsiang‐Chi, Wang Shih‐Han, Fang Guo‐Chen, Chou Wen‐Cheng, Liao Chun‐Che, Sun Cheng‐Pu, Jan Jia‐Tsrong, Ma Hsiu‐Hua, Ko Hui‐Ying, Ko Yi‐An, Chiang Ming‐Tsai, Liang Jian‐Jong, Kuo Chun‐Tse, Lee Te‐An, Morales‐Scheihing Diego, Shen Chen‐Yang, Chen Shih‐Yu, McCullough Louise D., Cui Lu, Wernig Gerlinde, Tao Mi‐Hua, Lin Yi‐Ling, Chang Yao‐Ming, Wang Shu‐Ping, Lai Yun‐Ju, Li Chia‐Wei. Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion. Journal of Medical Virology. 95(2), e28478, 2023-01-07. [JCR] [WOS]
- Hsieh Wan-Chen, Budiarto Bugi Ratno, Wang Yi-Fu, Lin Chih-Yu, Gwo Mao-Chun, So Dorothy Kazuno, Tzeng Yi-Shiuan, Chen Shih-Yu. Spatial multi-omics analyses of the tumor immune microenvironment. Journal of Biomedical Science. 29(1), 96, 2022-11-14. [JCR] [WOS]
- Thio Christina Li-Ping, Lai Alan Chuan-Ying, Wang Jo-Chiao, Chi Po-Yu, Chang Ya-Lin, Ting Yu-Tse, Chen Shih-Yu, Chang Ya-Jen. Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter–induced airway inflammation. JCI Insight. 7(23), e164157, 2022. [JCR] [WOS]
- Coskun Ahmet F., Han Guojun, Ganesh Shambavi, Chen Shih-Yu, Clavé Xavier Rovira, Harmsen Stefan, Jiang Sizun, Schürch Christian M., Bai Yunhao, Hitzman Chuck, Nolan Garry P. Nanoscopic subcellular imaging enabled by ion beam tomography. Nature Communications. 12(1), 789, 2021-02. [JCR] [WOS]
- Guan Y, Enejder A, Wang M, Fang Z, Cui L, (Chen SY), Wang J, Tan Y, Wu M, Chen X, Johansson PK, Osman I, Kunimoto K, Russo P, Heilshorn SC, Peltz G. A human multi-lineage hepatic organoid model for liver fibrosis. Nature communications. 12(1), 6138, 2021. [JCR] [WOS]
- Weng Rueyhung R., Lu Hsuan-Hsuan, Lin Chien-Ting, Fan Chia-Chi, Lin Rong-Shan, Huang Tai-Chung, Lin Shu-Yung, Huang Yi-Jhen, Juan Yi-Hsiu, Wu Yi-Chieh, Hung Zheng-Ci, Liu Chi, Lin Xuan-Hui, Hsieh Wan-Chen, Chiu Tzu-Yuan, Liao Jung-Chi, Chiu Yen-Ling, Chen Shih-Yu, Yu Chong-Jen, Tsai Hsing-Chen. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer. Nature Communications. 12(1), 2163, 2021. [JCR] [WOS]
- Gonzalez Veronica D., Huang Ying-Wen, Delgado-Gonzalez Antonio, Chen Shih-Yu, Donoso Kenyi, Sachs Karen, Gentles Andrew J., Allard Grace M., Kolahi Kevin S., Howitt Brooke E., Porpiglia Ermelinda, Fantl Wendy J. High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment. Cell Reports. 36(9), 109632, 2021. [JCR] [WOS]
- Huang HC, Liao CC, Wang SH, Lee IJ, Lee TA, Hsu JM, Kuo CT, Wang J, Hsieh WC, Chang SJ, Chen SY, Tao MH, Lin YL, Lai YJ, Li CW. Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis. American journal of cancer research. 11(10), 4994-5005, 2021. [JCR] [WOS]
- Hsu Tsung-Yuan, Hsu Ling-Nung, Chen Shih-Yu, Juang Bi-Tzen. MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease. Cells. 10(12), 3457, 2021. [JCR] [WOS]
- Hsieh Wan-Chen, Lai En-Yu, Liu Yu-Ting, Wang Yi-Fu, Tzeng Yi-Shiuan, Cui Lu, Lai Yun-Ju, Huang Hsiang-Chi, Huang Jia-Hsin, Ni Hung-Chih, Tsai Dong-Yan, Liang Jian-Jong, Liao Chun-Che, Lu Ya-Ting, Jiang Laurence, Liu Ming-Tsan, Wang Jann-Tay, Chang Sui-Yuan, Chen Chung-Yu, Tsai Hsing-Chen, Chang Yao-Ming, Wernig Gerlinde, Li Chia-Wei, Lin Kuo-I, Lin Yi-Ling, Tsai Huai-Kuang, Huang Yen-Tsung, Chen Shih-Yu*. NK cell receptor and ligand composition influences the clearance of SARS-CoV-2. Journal of Clinical Investigation. 131(21), e146408, 2021. [JCR] [WOS]
- Cui Lu*, Chen Shih-Yu*, Lerbs Tristan, Lee Jin-Wook, Domizi Pablo, Gordon Sydney, Kim Yong-hun, Nolan Garry, Betancur Paola, Wernig Gerlinde. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nature Communications. 11(1), 2020-06. [JCR] [WOS]
- Nair Nitya, Chen Shih-Yu, Lemmens Ed, Chang Serena, Le Dung T., Jaffee Elizabeth M., Murphy Aimee, Whiting Chan, Müller Thomas, Brockstedt Dirk G. Single cell immune competency signatures associate with survival in phase 2 GVAX and CRS-207 randomized studies in metastatic pancreatic cancer patients. Cancer Immunology Research. 8(5),609-617, 2020-05. [JCR] [WOS]